keratinasa para la piel
здоровье кожи, Кожа, Эксперты pbserum | 11 April 2025

Keratinase PB333: Your Best Ally for a Healthier, More Radiant Skin

In recent years, there has been a remarkable shift in the demand for medical-aesthetic procedures. More individuals are choosing less invasive treatments that require little to no recovery time, focusing on tissue recovery and prevention. These approaches prioritize skin health and avoid treatments that could damage the treated areas. 

With this in mind, and in the quest to improve skin quality, pbserum has achieved a revolutionary breakthrough in biotechnological research: the development of a highly innovative recombinant enzyme that stands out as the only one of its kind on the market-Keratinase PB333. This enzyme is the cornerstone of the Smartker Professional topical line and is also present in the Specific and Smartker home care lines. 

But what exactly is Keratinase PB333 and how does it work? Let’s dive in. 

What is Keratinase and how does it work? 

Keratinase PB333 is a recombinant enzyme derived through bacterial genetic recombination. Its remarkable efficacy lies in its high selectivity for a specific substrate: the keratin filaments concentrated in the stratum corneum of the epidermis. More specifically, it targets the corneodesmosomes, structures that hold corneocytes together and provide the skin with a protective barrier against external factors. 

Through this selective mechanism, Keratinase PB333 temporarily increases skin permeability by transiently degrading keratin and creating “channels” that allow the active ingredients of the various formulations to penetrate deeper into the epidermis. This mechanism brings two notable benefits: 

  1. Increased Retention of Active Ingredients: Ingredients remain active in the skin for up to nine times longer than with other topical treatments. Once inside, the keratin filaments in the corneocytes regain their integrity after a few hours, ensuring no long-term damage. 
  1. Cell Renewal: By targeting the basal layer, Keratinase PB333 stimulates the epidermal cycle, promoting healthy skin regeneration. 

The Importance of Combining Clinical Procedures with Home Care   

It is crucial to emphasize that any in-office skin treatment should ideally be complemented by a home care regimen. This combination amplifies the effects, sustains the results and enhances skin health and appearance. The inclusion of products containing Keratinase PB333 in home care regimens ensures effective and safe treatments. 

Commonly Treated Areas  

Some of the most frequently treated with areas using Keratinase PB333 include: 

  • Face: Improves tone, texture and hydration. 
  • Periocular region: Reduces signs of aging such as fine wrinkles and hyperpigmentation. 
  • Neck and Hands: Increases firmness, elasticity and evens skin tone. 
  • Post-Treatment Care: Aids in repairing skin after procedures addressing stretch marks and post-acne scars. 

Backed by Science: The Efficacy of Keratinase PB333

One of the outstanding qualities of Keratinase PB333 is its strong scientific support. The development of this enzyme is supported by in vitro studies and 10 clinical trials involving over 200 patients, all yielding statistically significant results. Here are some of the key findings: 

  • Safety and Satisfaction: No adverse skin effects were observed, and patients reported high levels of satisfaction. 
  • Measurable Improvements: The studies showed an average improvement of 35% in several key areas, including:  
  • Evening Skin Tone and Reduction of Imperfections: Achieving a more uniform complexion. 
  • Sebum Production: A noticeable reduction in excess sebum. 
  • Skin Texture and Hydration: Reduced roughness and deep hydration. 
  • Elasticity and Firmness: Significant improvements in skin´s structural resilience. 
  • Pigmentation Reduction: Visible improvement in skin tone and brightness. 

How Keratinase PB333 Transforms Skin Health 

The transformative potential of this enzyme lies in its unique properties and precise action. Unlike abrasive treatments or chemical peels that may compromise the skin´s barrier, Keratinase PB333 works in harmoniously with the skin’s natural processes, by selectively targeting and degrading keratin, it opens channels for active ingredients without causing long-term damage. This temporary permeability not only improves the absorption of active compounds but also facilitates better cell communication and regeneration. 

Moreover, Keratinase PB333 provides a versatile solution to address a variety of skin concerns, from aging signs to acne scar repair. Its ability to stimulate the basal layer and promote cellular renewal ensures visible and lasting improvements in skin health and appearance. 

Clinical Procedures and Home Care: A Winning Combination 

For optimal results, it is essential to combine clinical procedures with at-home maintenance. Professional treatments using Keratinase PB333 can initiate skin´s transformation, while home- care products help maintain and enhance these results over time. This synergy ensures that patients enjoy longer-lasting benefits and a noticeable improvement in the overall skin condition. 

Why Choose Products with Keratinase PB333?

  1. Efficacy: Achieves results comparable to more invasive treatments without the associated risks or downtime. 
  1. Safety: Supported by rigorous scientific research, ensuring no harm on the skin’s natural barrier. 
  1. Versatility: Suitable for a wide range of skin types and conditions, making it a valuable tool in both clinical and home care settings. 

A Revolution in Skin Care 

Keratinase PB333 represents a significant breakthrough in aesthetic and medical skin care. Developed through advanced genetic recombination processes, this enzyme is the basis for several pbserum treatment lines and is positioned as an innovative and effective tool for both in-office and home care procedures.  

Its high selectivity for its specific substrate guarantees effective and safe results, without compromising the integrity of the skin barrier, thus promoting healthier and more radiant skin. 

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