the-role-of-recombinant-enzymes
Skin health, The skin | 13 January 2025

The role of recombinant enzymes in aesthetic medicine

What are recombinant enzymes?

Recombinant pbserum enzymes are the result of a unique biotechnological process that utilizes the technology of genetic recombination of DNA, called recombinant technology.

The objective of this process is to obtain enzymes made by bacteria that will have the same structure and sequence as human enzymes. This makes the procedure unique in aesthetic medicine offering a low level of immunogenicity, allowing a safe, effective and pure treatment.

Types of recombinant enzymes

Thanks to them, an infinite horizon of new possibilities and highly effective treatments with great capacity for personalization has been opened. pbserum enzymes are different from other products on the market because the recombinant technology used is unique. This ensures purity, consistency and efficacy. The different types are:

  • Keratinase : promotes cell regeneration and improves permeability, while respecting the cutaneous barrier and enhancing the retention of active ingredients up to 9 times.
  • Hyaluronidase: aids in the dissolution of hyaluronic acid. Hyaluronidase is used to aid in the dissolution of hyaluronic acid previously injected in other procedures. pbserum hyaluronidase has been specifically designed for hyaluronic acid corrections and complications.
  • Collagenase: pbserum offers 2 varieties of collagenases that act synergistically by disintegrating aged collagen fibers and promote the generation of new fibers by fibroblasts.
  • Lipase: activates lipid metabolism, helps to break down localized fat without damaging the tissue. This enzyme is very effective as it reduces localized fat by improving adipose tissue.
  • Lyase: increases tissue permeability improving fluid retention.

What are they used for?

The application of enzymes has many benefits, they are used in aesthetic medicine for different indications, in particular for treatments of facial rejuvenation and body remodeling. Some of the most common uses in aesthetic medicine include:

  • Localized fat removal: Lipoenzymes are used to dissolve and remove unwanted fat accumulations in different areas of the body. For example, the use of the enzyme called lipase is very common to eliminate localized fat.
  • Cellulite treatment: Recombinant enzymes are used to treat cellulite by breaking down collagen fibers. This helps to improve the appearance of orange peel skin.
  • Facial rejuvenation: they renew collagen and elastin, providing rejuvenation and repair to the skin.
  • Double chin treatment: helps to define the jaw contour in a natural way without a volumizing effect.
  • Facial contouring: improvement of the contour of the face thanks to recombinant enzymes, you can find more information in the article about what is facial contouring.
  • Collagen stimulation: used to increase collagen production in the skin. This can improve skin firmness, texture and elasticity.
  • Scar and acne mark removal: can be used to help soften scars and improve the appearance of acne marks.
  • Fibrosis treatment: enzymes are an innovative alternative for tissue remodeling in an indication with few therapeutic options offering fast and lasting results. It improves the functionality and appearance of the skin.

Why use recombinant enzymes?

Recombinant enzymes offer many advantages in facial and body treatments:

  • Greater precision in the action: due to the specificity of the enzymes, they only act on the desired tissue. Visible and lasting effects from the first session. In addition, the number of sessions required is lower compared to other treatments.
  • Efficiency and safety: unique and synergistic tissue remodeling effect. Highly safe treatment, knowing its origin considerably minimizes the danger of adverse responses. No side effects.
  • High customization capacity: The use of recombinant enzymes allows for tailoring treatments to different cases and has high compatibility with other procedures.
  • Treatment without aesthetic footprint. As mentioned in our article on natural results in aesthetic medicine, enzyme treatments follow this trend.

Recombinant enzymes in Spain

The pbserum brand is the only one in the world that has 5 enzymes developed and produced in-house. These are Keratinase PB333, Hyaluronase PB300, Collagenase G/H PB220, Lipase PB500 and Lyase PB72K. They are obtained using the most advanced recombinant technology.

This has allowed the creation of a complete portfolio of enzymatic treatments: Smartker, Specific, Plus, HA Low Medium High and HA Corrector.

If you are a patient, ask your trusted doctor about enzyme treatments. If you are a doctor, you can learn more about enzymes on our private platform for professionals.