The only recombinant enzymatic system in the world
What is HA?
HA Low, Medium & High is a line a of products based on enzymatic system that have been clinically formulated to treat a range of specific indications, both facial and corporal.
How does it work?
HA Low, Medium & High enzymatic system combines different enzymes that work synergistically: Collagenases PB220 break down non-functional collagen and stimulate the production of new collagen fibers; Lipase PB500 effectively reduces adipose tissue volume; and Lyase PB72K enhances fluid drainage and tissue permeability
Products
HA Low*
Injectable medical device developed to restore firmness and elasticity in areas with flaccid or atrophic fibrosis. Its balanced enzyme complex supports tissue revitalization and structural recovery, improving tone and texture while maintaining natural facial contours and skin integrity.
HA Medium*
Injectable medical device designed to target localized fatty fibrosis. Combining lipase, collagenase, and lyase, it promotes enzymatic remodeling of fibrotic tissue, improving contour and firmness in areas affected by accumulated fat or moderate fibrosis, and enhancing skin quality while reducing recovery time.
HA High*
Injectable medical device developed to restore firmness and elasticity in areas with flaccid or atrophic fibrosis. Its balanced enzyme complex supports tissue revitalization and structural recovery, improving tone and texture while maintaining natural facial contours and skin integrity.
Results
Patient satisfaction up to 95%(1)
0% of severe adverse effects reported.(1)
Significant improvements in various parameters of scar fibrosis(2)
Before/After
Face reshaping
Author: Dr. Eduardo Ortega (Perú)
Double chin
Author: Dr. Claudio A. Freixes (México)
Localized fat
Author: Dra. Marcela Alpirez (Guatemala)
Cellulite
Author: Dra. Mariana Martha Cruz Roncal (México)
Post surgical fibrosis
Author: Dra. Loira Ronquillo (Ecuador)
Scars
Author: Dra. Maira González (Venezuela)
Doctor's opinion
"The potential of pbserum is immense; it is an effective and safe treatment that I include in my daily clinical practice and is the only one based on recombinant enzymes with sanitary registration."
"The effect of pbserum products is noticeable from the first application, as they work on different layers of the skin. For double chin, it reduces fat tissue at the hypodermis level and significantly improves skin quality."
Dra. Sonya Valkova
Dermatologist
Frequently
Asked
Questions
Experience shows a synergistic action of the enzyme cocktail compared to the potency of each enzyme separately. Almost all pathologies treated with the pbserum product line include a component of fibrosis with atrophy or hypertrophy due to alteration of collagen structure (substrate of collagenases G/H) and accumulated adipose tissue (substrate of lipase), while lyase reduces local edema and ECM viscosity, facilitating the diffusion of the remaining enzymes. The joint action promotes tissue remodeling, since the degradation of specific substrates promotes chemotaxis and fibroblast action, with formation of new collagen and elastin fibers.
- Degree of Satisfaction of Patients Treated Cosmetically with Recombinant Enzymes; Clinical Experience https://doi.org/10.34141/LJCS9643178
*López Gehrke I, Soto Montenegro AE, Santaella E, Prada Castellanos Y, López Berroa J. Grado de satisfacción de pacientes tratados estéticamente con enzimas recombinantes; experiencia clínica. Lat Am J Clin Sci Med Technol. 2024 Mar; 6: 30 – 38. - Multicenter Clinical Study to Evaluate the Efficacy and Safety of Hyaluronic Acid and Enzyme Cocktail in Scars;
*De Castro GMP, Muñoz MJR. Multicenter Clinical Study to Evaluate the Efficacy and Safety of Hyaluronic Acid and Enzyme Cocktail in Scars. Dermatología Cosmética, Médica y Quirúrgica. 2020;18(2):84-92
*Depending on the registration and regulations in each country, the product name may vary as HA 2.0 Low / Medium / High or HA 1.5 Low / Medium / High. The packaging format or design may also differ depending on the country or region.