The only recombinant enzymatic system in the world
What is pbserum HA?
pbserum HA* is a non-cross-linked, high molecular weight hyaluronic acid (without a filling function).
pbserum HA Low Medium High is a line a of products based on enzymatic system that have been clinically formulated to treat a range of specific indications, both facial and corporal.
*HA 2.0 is a CE certified medical device.
How does it work?
pbserum HA* acts favoring the tissue regeneration, through the action of hyaluronic acid in the debridement of fibrous scar tissue thanks to its anti-adherent properties, improving characteristic parameters of scars such as vascularization, pigmentation, thickness, elasticity, pain and pruritus.
pbserum HA Low Medium High enzymatic system combines different enzymes that work synergistically: Collagenases PB220 break down non-functional collagen and stimulate the production of new collagen fibers; Lipase PB500 effectively reduces adipose tissue volume; and Lyase PB72K enhances fluid drainage and tissue permeability.
The tissue remodeling effect induced by the HA* and HA Low Medium High product lines not only enhances skin appearance but also improves its quality and promotes tissue regeneration at the application site.
*HA 2.0 is a CE certified medical device.
Products
pbserum HA
Debridement of fibrous scar tissue.
HA Low
Presentation designed for facial reshaping.
HA Medium
Presentation designed for double chin, localized fat and cellulite.
HA High
Presentation designed for scars and postsurgical fibrosis.
Results
Patient satisfaction up to 95%(1)
0% of severe adverse effects reported.(1)
Significant improvements in various parameters of scar fibrosis(2)
Before/After
Face reshaping
Author: Dr. Eduardo Ortega (Perú)
Double chin
Author: Dr. Claudio A. Freixes (México)
Localized fat
Author: Dra. Marcela Alpirez (Guatemala)
Cellulite
Author: Dra. Mariana Martha Cruz Roncal (México)
Post surgical fibrosis
Author: Dra. Loira Ronquillo (Ecuador)
Scars
Author: Dra. Maira González (Venezuela)
Doctor's opinion
"The potential of pbserum is immense; it is an effective and safe treatment that I include in my daily clinical practice and is the only one based on recombinant enzymes with sanitary registration."
"The effect of pbserum products is noticeable from the first application, as they work on different layers of the skin. For double chin, it reduces fat tissue at the hypodermis level and significantly improves skin quality."
Dra. Sonya Valkova
Dermatologist
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Frequently
Asked
Questions
Experience shows a synergistic action of the enzyme cocktail compared to the potency of each enzyme separately. Almost all pathologies treated with the pbserum product line include a component of fibrosis with atrophy or hypertrophy due to alteration of collagen structure (substrate of collagenases G/H) and accumulated adipose tissue (substrate of lipase), while lyase reduces local edema and ECM viscosity, facilitating the diffusion of the remaining enzymes. The joint action promotes tissue remodeling, since the degradation of specific substrates promotes chemotaxis and fibroblast action, with formation of new collagen and elastin fibers.
- Degree of Satisfaction of Patients Treated Cosmetically with Recombinant Enzymes; Clinical Experience https://doi.org/10.34141/LJCS9643178
*López Gehrke I, Soto Montenegro AE, Santaella E, Prada Castellanos Y, López Berroa J. Grado de satisfacción de pacientes tratados estéticamente con enzimas recombinantes; experiencia clínica. Lat Am J Clin Sci Med Technol. 2024 Mar; 6: 30 – 38. - Multicenter Clinical Study to Evaluate the Efficacy and Safety of Hyaluronic Acid and Enzyme Cocktail in Scars;
*De Castro GMP, Muñoz MJR. Multicenter Clinical Study to Evaluate the Efficacy and Safety of Hyaluronic Acid and Enzyme Cocktail in Scars. Dermatología Cosmética, Médica y Quirúrgica. 2020;18(2):84-92