flacidez-facial-enzimas-recombinantes
Skin health, The skin | 17 December 2024

Skin revitalization and treatment of skin flaccidity with recombinant enzymes

Facial sagging treatment greatly benefits from the huge advances in genetic engineering and molecular biology techniques. In this article, we explain how recombinant enzymes are revolutionizing skin firmness treatments, along with the active ingredients, their mechanism of action and extraordinary benefits, translate into skin revitalization.

What is skin flaccidity?

Skin flaccidity is the loss of firmness and elasticity of the skin and other facial structures. Over time, chrono-aging (physiological aging associated with age) decreases the production of essential structural proteins, such as collagen, elastin and Hyaluronic acid, crucial for maintaining skin hydration.


The loss of skin tone and firmness makes it thinner and more flaccid, which, together with other structures displacement, results in the formation of folds and grooves, as well as visible wrinkles, especially in certain zones such as the corners of the mouth, jawline, nasolabial folds, eyelids, neck and double chin.

In addition to chrono-aging, there are other secondary causes that lead to the loss of skin elasticity:

  • Excesive sun exposure (photo-aging)
  • Smoking. Tobacco smoke causes poor lung oxigen supply and accelerates the process of cellular oxidation.
  • Fast and excessive weight changes
  • Genetic predisposition
  • Sedentary lifestyle
  • Low protein intake

How can I identify facial sagging?

Skin flaccidity is gradually developed. Chrono-aging and its consequences reveal changes on the skin face; the forehead, eyelids, eyebrows, and the lower third of the face, are the first areas that show loss of support and skin elasticity.

The progressive loss of skin firmness and the weakening of other facial structures lead to the appearance of some of the most common signs of facial sagging:

  • Droopy eyelids, resulting in an aged and tired appearance.
  • Eyebags, which can cause water retention, edema, and swelling.
  • Deeper and more visible wrinkles
  • Cheek volume loss, sunken skin, and more pronounced nasolabial folds.
  • Perioral wrinkles (bar-code) and wrinkles at the corners of the mouth.
  • Progressive drooping of the nose tip and loss of the face´s natural contour.
  • Skin neck loss of firmness and thickening appearance of the centre of the chin.

These aging signs are also associated with diminished skin luminosity and hydration loss.

Treatments with recombinant enzymes to restore facial skin firmness

One of the main objectives of the aesthetic field is to prevent the effects of chrono-aging, particularly, loss of skin elasticity and firmness. The most advanced techniques in molecular engineering enable the application of new treatments based on highly specific enzymes obtained via recombinant technology, which act effectively on the right substrate with minimal to no immunogenic potential.
The Smartker Firmness Professional treatment is designed to improve skin firmness using recombinant enzymes such as Keratinase, the key component of the line and responsible for its multiple benefits, and collagenase, along with other active ingredients working in synergy to hydrate, play a role as antioxidants and improve muscle tone.

The care protocol is completed with Smartker Firmness Daily, a treatment formulated with the same active ingredients and designed to treat at -home use to address the loss of firmness and elasticity, repairing skin flaccidity.

Keratinase PB333 and its role in the treatment

Keratinase PB333 is key component of the smartker Firmness Professional treatment, and playing a crucial role in cellular renewal with and intelligent peeling effect. This enzyme removes excess  dead cells without causing irritation, improving skin texture by increasing its permeability and promoting the penetration and retention of the active ingredients into the deeper layers of the epidermis, where they exert their full potential.

Collagenase: how  it helps rejuvenate your skin

pbserum collagenase is a combination of G and H collagenases with a positive effect on improving skin quality by eliminating erratic or non-functional collagen fibers. These enhances the activity of fibroblasts, which in turn remodel and redistribute new, higher-quality collagen and elastin fibers, and hyaluronic acid formation.

Hyaluronic Acid and Vitamin C Contribution

High and low molecular weight hyaluronic acid promotes deep hydration, fills fine wrinkles, and improves skin firmness. On the other hand, vitamin C has a high antioxidant capacity that protects against UV radiation and prevents hyperpigmentation. Furthermore, it is essential in the synthesis process of new collagen fibers.

DMAE and its impact on skin elasticity and firmness

DMAE (dimethylaminoethanol) is a powerful active ingredient highly effective against skin aging. Its onset starts the instant it is applied (flash effect) increasing muscle tone and enhancing skin firmness and elasticity.

Keratinase benefits in the treatment of skin flaccidity

The innovative Smartker Firmness professional treatment is based on the enzyme Keratinase PB333, an enzyme developed internally by Proteos Biotech. It is the key to the only intelligent action facial line suitable for all skin types.

Improve the texture and skin tone

Keratinase recognizes the skin´s needs acting where neessary, removing excess dead cells in the stratum corneum without causing irritation or tissue damage, and promoting cellular renewal.

Longlasting effects in firmness and elasticity

Due to its proteolytic properties, Keratinase degrades the peptide bonds in keratin, which accelerates the physiological process of epidermal renewal, by increasing the permeability and creating channels that enable the penetration of active ingredients to deeper layers of the skin, resulting in more efficient and long-lasting outcomes.

Development of skin flaccidity through time

We clarify the differences in facial sagging at different ages. Facial flaccidiy is a gradual process commonly associated with chrono-aging, As such, it is important to start and maintain a skincare routine as the first signs become evident.

Facial sagging at 30

How to rejuvenate the face at 30 years old? The best way to maintain face smoothness and radiance is to follow a balanced and healthy diet, exercise regularly, get adequate rest and use appropriate skin care with the right products.
What happens to the skin at 30 years old? From this age on, the skin starts to lose elasticity, volume, and luminosity, due to both biological and environmental factors.
What wrinkles appear at 30 years old? In this decade of life, small and fine lines begin to form, highlighting the importance to address aging signs.

Facial flaccidity at 40

How to rejuvenate facial skin after 40? It is advisable to seek professional assessment about the most convenient and personalized treatment according to the skin´s needs.
What’s best for facial flaccidity? At 40, the skin´s regenerative capacity, as well as collagen asn elastin production, gradually decreases, leading to the early onset of skin flaccidity. Healthy habits and regular skincare treatments are fundamental when addressing facial laxity.
How to stop facial sagging? The use of products and treatments both professional and at- home, manufactured with the best active ingredients and supported by scientific investigation, is the most effective way to stop facial flaccidity.

Facial flaccidity at 50

How to rejuvenate the face at 50 years old? The 50s bring hormonal and metabolic changes, at the skin level, such as dryness, skin thinning, wrinkles, and facial laxity. The solution is to undergo treatments with highly effective products and long-lasting effects.

Which cream is the most suitable for treating skin flaccidity? Choose treatments that reverse or regenerate the loss of skin firmness and elasticity, acting in deeper layers of the epidermis, providing hydration, antioxidant capacity, and skin revitalization.

Professional consultation: a necessary step

To maximize the benefits of the use of recombinant enzymes, it is fundamental to consult with a medical professional to personalize the treatment based on the specific needs and age of each patient. Discuss treatment options with your doctor and get an adequate assessment for a proper application.