Scars and post-surgical fibrosis, The skin, Uncategorized | 6 March 2025

Complete guide to treat post-surgical fibrosis and improve skin regeneration

Post-surgical fibrosis can affect the quality of life after surgery. Did you know that a treatment for post-surgical fibrosis based on enzyme therapy for the skin is available? pbserum’s HA High enzyme treatment has been specifically designed to treat post-surgical fibrosis. This treatment contains the enzymes Collagenase PB220, Lipase PB500 and Lyase PB72K, which act synergistically on the affected tissues, reorganizing the extracellular matrix and reducing fibrous tissue. 

What is post-surgical fibrosis and how does it affect the skin?

Any surgical intervention involves trauma to the skin in the area affected by the surgery. Immediately, the process of wound repair and skin regeneration begins. This is a complex process comprising four phases:  

  • Coagulation. Phase in which a clot is formed to seal the wound and prevent fluid loss.  
  • Inflammation. Defensive phase in which the immune system protects tissues from possible infections. 
  • Proliferation. Phase in which the so-called “granulation tissue” is formed, consisting of new capillaries and various types of cells, including fibroblasts, which are responsible for producing collagen and other extracellular matrix proteins that form the structure of the new tissue. 
  • Maturation. In this phase, the collagen fibers are reorganized and the tissue regenerates, gaining resistance, strength and flexibility. 

To effectively combat this process, pbserum HA High treatment reorganizes the extracellular matrix, degrades non-functional collagen fibers in fibrous tissue, decreases edema and adhesions, and improves the appearance and functionality of the affected skin. 

Post-surgical fibrosis is the excessive formation of fibrous tissue due to an imbalance in the production, above all, of collagen fibers. This tissue is denser and less elastic, which can cause discomfort, pain, lack of mobility and esthetic alterations. 

Common causes of post-surgical fibrosis

We have already explained that post-surgical fibrosis is a consequence of an exaggerated alteration of the healing process and can occur in any patient who undergoes surgery. However, there are factors that can favor the appearance of fibrosis.  

These are the most common causes of post-surgical fibrosis

  • Type of surgical intervention. More invasive surgeries, in which large incisions must be made, involve a greater risk of post-surgical fibrosis. After liposuction, the surgical method, if it is more extensive or involves greater tissue manipulation, may increase the risk of fibrosis. 
  • Individual predisposition. Factors such as health status or genetics may contribute to the development of post-surgical fibrosis. 
  • Post-operative care. Inadequate postoperative care can lead to alteration of the healing process and the appearance of fibrosis. 

How to recognize post-surgical fibrosis?

The symptoms of post-surgical fibrosis can change from one person to another or depending on the type of surgery undergone. We detail the most frequent effects of fibrosis:  

  • Discomfort or pain in the area of the intervention. 
  • Swelling and inflammation.  
  • Numbness. 
  • Hardening of the skin. 
  • Changes in skin texture. 
  • Stiffness around the area of the intervention. 
  • Decreased range of motion in the affected area. 

Prevention of post-surgical fibrosis

To avoid the appearance of post-surgical fibrosis, it is essential to follow a series of post-surgical cares that favor a correct healing and regeneration of the skin.  

Prevention methods

In addition to following your doctor’s instructions, here are some key recommendations that may help you: 

  • Follow postoperative instructions: Be sure to comply with the care recommended by your surgeon, such as the application of specific creams or medications, as well as attending your post-surgical check-ups. 
  • Maintain adequate hydration: Water is essential for the healing process, so it is important to drink enough fluids and apply products that keep the skin hydrated. 
  • Moderate exercise: When prescribed by your doctor, light exercise can improve circulation, helping to prevent fibrosis from forming. 
  • Take care of your diet: A balanced diet rich in nutrients promotes tissue regeneration, which contributes to optimal healing. 
  • Compression garments: In some surgeries, such as liposuction, the use of compression garments can reduce swelling and improve healing. 

Enzymatic treatments for post-surgical fibrosis

pbserum’s HA High treatment has been specifically designed for scars and post-surgical fibrosis. The treatment contains the enzymes Collagenase PB220, Lipase PB500 and Lyase PB72K, which act on the tissues to decrease or eliminate postoperative fibrosis and achieve permanent results.  

The synergistic action of the three enzymes acts directly on the fibrotic septum, which contributes to the breakdown of scar tissue, reorganizes the extracellular matrix, reduces edema and adhesions and improves the appearance and functionality of the affected skin. 

pbserum’s HA High enzyme treatment is specifically formulated to reduce post-surgical scarring and fibrosis. Visible results include improved elasticity of the affected tissue, decreased scar size, and a faster return of mobility in the affected area. 

Benefits of recombinant enzymes

The recombinant pbserum enzymes, Collagenase PB220, Lipase PB500 and Lyase PB72K, whose active ingredients are collagenase, lipase and lyase, play a prominent role in tissue regeneration mechanisms and provide important benefits in the regenerative treatment of the skin. These are the main advantages of their use: 

  • Treatments formulated with recombinant enzymes are minimally invasive and respectful of tissue integrity. 
  • These treatments are based on the quality and safety provided by pbserum’s exclusive complex biotechnological process. 
  • As they are non-invasive treatments, they do not require recovery time after use and the risk of side effects is minimized. 
  • Recombinant enzyme treatments stand out for their specificity, as they address each pathology or skin disorder, as in the case of HA High treatment for post-surgical fibrosis or Specific Acne Scars treatment mentioned in the article How to erase acne scars? Tips and effective treatments. 
  • They are biocompatible treatments. The risk of adverse reactions is minimized, unlike treatments with conventional chemical products. 
  • Recombinant enzyme treatments are suitable for all skin types and can be applied at all times of the year. 
  • The doctor can use other techniques along with recombinant enzyme treatments and establish a protocol appropriate for each person in which they are applied before or after a few days, to allow the enzymes to act and fulfill their function. 

What results can be expected after an enzymatic treatment?

The HA High enzyme system of pbserum is specifically formulated for the treatment of fibrosis as it achieves a change in colour as well as improving the mobility of the affected tissue and promoting a rapid return to functionality. For best results, a minimum of 3 sessions is recommended.

pbserum recombinant enzymes are the result of years of biotechnological research. They are proteins of bacterial origin developed with a recombinant technology that allows obtaining high purity, effective and safe enzymes. The result is highly specific and effective products, such as HA Low, HA Medium and HA High, for the treatment of different aesthetic medicine conditions.  

To learn more about these innovative treatments and which one is best for you, contact a certified specialist.