The only recombinant enzymatic system in the world
What is HA 1.5?
HA 1.5 Low Medium & High is a line a of products based on enzymatic system that have been clinically formulated to treat a range of specific indications, both facial and corporal.
How does it work?
HA 1.5 Low Medium & High enzymatic system combines different enzymes that work synergistically: Collagenases PB220 break down non-functional collagen and stimulate the production of new collagen fibers; Lipase PB500 effectively reduces adipose tissue volume; and Lyase PB72K enhances fluid drainage and tissue permeability
Products
HA 1.5 Low
Improves skin firmness and tissue quality in areas with loss of tone.
Formulated to address flaccid fibrosis, this solution combines lipase, collagenase, and lyase, making it ideal for facial remodeling without adding volume and while preserving natural facial contours.
HA 1.5 Medium
Redefines areas with fat accumulation and loss of contour.
Formulated to treat moderate fibrosis, double chin, or cellulite. Its high concentration of lipase allows it to act effectively on the tissue, delivering visible results with reduced recovery time.
HA 1.5 High
Softens thickened tissue and enhances its mobility.
Recommended in cases of severe fibrosis, including scarring or post-surgical outcomes. Its collagenase-rich formula supports progressive skin regeneration, improving texture and elasticity over time.
Results
Patient satisfaction up to 95%(1)
0% of severe adverse effects reported.(1)
Significant improvements in various parameters of scar fibrosis(2)
Before/After
Face reshaping
Author: Dr. Eduardo Ortega (Perú)
Double chin
Author: Dr. Claudio A. Freixes (México)
Localized fat
Author: Dra. Marcela Alpirez (Guatemala)
Cellulite
Author: Dra. Mariana Martha Cruz Roncal (México)
Post surgical fibrosis
Author: Dra. Loira Ronquillo (Ecuador)
Scars
Author: Dra. Maira González (Venezuela)
Doctor's opinion
"The potential of pbserum is immense; it is an effective and safe treatment that I include in my daily clinical practice and is the only one based on recombinant enzymes with sanitary registration."
"The effect of pbserum products is noticeable from the first application, as they work on different layers of the skin. For double chin, it reduces fat tissue at the hypodermis level and significantly improves skin quality."
Dra. Sonya Valkova
Dermatologist
Frequently
Asked
Questions
Experience shows a synergistic action of the enzyme cocktail compared to the potency of each enzyme separately. Almost all pathologies treated with the pbserum product line include a component of fibrosis with atrophy or hypertrophy due to alteration of collagen structure (substrate of collagenases G/H) and accumulated adipose tissue (substrate of lipase), while lyase reduces local edema and ECM viscosity, facilitating the diffusion of the remaining enzymes. The joint action promotes tissue remodeling, since the degradation of specific substrates promotes chemotaxis and fibroblast action, with formation of new collagen and elastin fibers.
- Degree of Satisfaction of Patients Treated Cosmetically with Recombinant Enzymes; Clinical Experience https://doi.org/10.34141/LJCS9643178
*López Gehrke I, Soto Montenegro AE, Santaella E, Prada Castellanos Y, López Berroa J. Grado de satisfacción de pacientes tratados estéticamente con enzimas recombinantes; experiencia clínica. Lat Am J Clin Sci Med Technol. 2024 Mar; 6: 30 – 38. - Multicenter Clinical Study to Evaluate the Efficacy and Safety of Hyaluronic Acid and Enzyme Cocktail in Scars;
*De Castro GMP, Muñoz MJR. Multicenter Clinical Study to Evaluate the Efficacy and Safety of Hyaluronic Acid and Enzyme Cocktail in Scars. Dermatología Cosmética, Médica y Quirúrgica. 2020;18(2):84-92