cabecera-lmh

The only recombinant enzymatic system in the world

What is HA 1.5?

HA 1.5 Low Medium & High is a line a of products based on enzymatic system that have been clinically formulated to treat a range of specific indications, both facial and corporal.

How does it work?

 HA 1.5 Low Medium & High enzymatic system combines different enzymes that work synergistically: Collagenases PB220 break down non-functional collagen and stimulate the production of new collagen fibers; Lipase PB500 effectively reduces adipose tissue volume; and Lyase PB72K enhances fluid drainage and tissue permeability

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Products

ha.15 low

HA 1.5 Low

Improves skin firmness and tissue quality in areas with loss of tone.
Formulated to address flaccid fibrosis, this solution combines lipase, collagenase, and lyase, making it ideal for facial remodeling without adding volume and while preserving natural facial contours.

ha.15 medium

HA 1.5 Medium

Redefines areas with fat accumulation and loss of contour.
Formulated to treat moderate fibrosis, double chin, or cellulite. Its high concentration of lipase allows it to act effectively on the tissue, delivering visible results with reduced recovery time.

ha.15 medium

HA 1.5 High

Softens thickened tissue and enhances its mobility.
Recommended in cases of severe fibrosis, including scarring or post-surgical outcomes. Its collagenase-rich formula supports progressive skin regeneration, improving texture and elasticity over time.

Results

Patient satisfaction up to 95%(1)

Recombinant enzyme treatment in aesthetic medicine yielded highly favorable results, with patient satisfaction ranging from 86.9% to 94.7% across various indications such as double chin, jowl, and localized fat.

0% of severe adverse effects reported.(1)

 

No serious adverse effects or complications were reported with the use of pbserum recombinant enzymes in over 200 patients from the clinical experience.

Significant improvements in various parameters of scar fibrosis(2)

 

Improvement in vascularity by up to 85%, reduction in rigidity by up to 55%, and reduction in pruritus by up to 68%.

Before/After

Doctor's opinion

Frequently
Asked
Questions

Experience shows a synergistic action of the enzyme cocktail compared to the potency of each enzyme separately. Almost all pathologies treated with the pbserum product line include a component of fibrosis with atrophy or hypertrophy due to alteration of collagen structure (substrate of collagenases G/H) and accumulated adipose tissue (substrate of lipase), while lyase reduces local edema and ECM viscosity, facilitating the diffusion of the remaining enzymes. The joint action promotes tissue remodeling, since the degradation of specific substrates promotes chemotaxis and fibroblast action, with formation of new collagen and elastin fibers.

  1. Degree of Satisfaction of Patients Treated Cosmetically with Recombinant Enzymes; Clinical Experience https://doi.org/10.34141/LJCS9643178
    *López Gehrke I, Soto Montenegro AE, Santaella E, Prada Castellanos Y, López Berroa J. Grado de satisfacción de pacientes tratados estéticamente con enzimas recombinantes; experiencia clínica. Lat Am J Clin Sci Med Technol. 2024 Mar; 6: 30 – 38.
  2. Multicenter Clinical Study to Evaluate the Efficacy and Safety of Hyaluronic Acid and Enzyme Cocktail in Scars;
    *De Castro GMP, Muñoz MJR. Multicenter Clinical Study to Evaluate the Efficacy and Safety of Hyaluronic Acid and Enzyme Cocktail in Scars. Dermatología Cosmética, Médica y Quirúrgica. 2020;18(2):84-92